Compared to the old collagen products (Zyderm & Zyplast), Evolence offers several advantages:
1) no need for a skin test prior to treatment to check for sensitivities or allergies, which happened in about 1% of people with the old product;
2) much longer-lasting correction. European studies show a duration of about 12 months; and
3) minimal bruising from the injection.
Overall, it looks promising, and we're now going to offer it in my practice, adding another option to the many other FDA-approved fillers we have.
What will be really interesting is a head-to-head comparison study comparing Evolence to some of the better hyaluronic gel fillers. This study is underway. "Which filler will reign supreme?"...we'll have to wait and see!